Everybody likes to speak about 3D Obturation, but clinically we cannot fill into areas of the root canal system where residual pulp tissue and their byproducts reside. The key is active versus passive disinfection. In this segment, we will look at disinfection in general. Specifically, the ten factors that influence disinfection will be reviewed and then the various methods available today that may be utilized to achieve this objective will be described. At the conclusion of this show, you will better understand and appreciate how these factors and methods serve to influence three-dimensional cleaning. Active irrigation is the secret to 3D cleaning and filling root canal systems.